Irreversible Electroporation (IRE) – When Electricity Destroys the Tumor

For some tumors, traditional surgery is not an option—for instance, because the tumor is located too close to major blood vessels. This is precisely where irreversible electroporation (IRE) can serve as a valuable alternative or complementary treatment. In some cases, it is the only way to remove the tumor. Irreversible electroporation (IRE) is a modern, minimally invasive method for treating tumors.

How does that work?

In IRE, thin needles are placed directly around the tumor. Short, targeted electrical pulses are delivered through these needles—similar to tiny flashes of lightning—which destroy all cells, including the tumor cells, within the treatment area. The structures of the blood vessel walls are largely spared, as very little heat is generated. The procedure takes only a few minutes and is performed under general anesthesia, usually during a major operation to subsequently remove the now-destroyed tumor. It can also be performed externally through the skin by specialized interventional radiologists if the tumor is very small (< 3 cm).

For which types of tumors is IRE an option?

IRE is primarily used to treat tumors of the pancreas, liver, and bile ducts—especially when direct surgery is not possible and other treatment methods are ineffective due to the tumor’s location. Studies also show that IRE, when combined with immunotherapy, could open up new possibilities.

In good hands at GITZ

This specialized procedure is performed by Prof. Dr. med. Jan Schmidt within our network.

Do you have any questions or would you like to discuss your case? We’re here to help—please contact GITZ directly at info@gitz.ch